Mise en œuvre du système de notation OMERACT pour l'imagerie par résonance magnétique du rhumatisme psoriasique dans une étude randomisée de phase IIb de l'abatacept dans le rhumatisme psoriasique
Rheumatology (Oxford) 2022 doi: 10.1093/rheumatology/keac073
In this study abatacept 30/10 mg/kg and 10 mg/kg doses were associated with greater improvements from baseline in MRI detected synovitis and tenosynovitis, respectively, compared with placebo, confirming the clinical outcomes. Indeed, inflammatory components demonstrated the greatest change from baseline.
This study sought to determine whether the novel scoring system OMERACT PsAMRIS shows sensitivity to change with an agent known to impact clinical outcomes in PsA. The results encourage further use of PsAMRIS scoring in observational cohorts and clinical trials for objective assessment of the influence of new drugs on joint inflammation and damage progression in PsA.
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