Efficacité des inhibiteurs du TNF, de l'abatacept, des inhibiteurs de l'IL6 et des inhibiteurs de JAK chez 31 846 patients atteints de polyarthrite rhumatoïde dans 19 registres de la collaboration "JAK-pot"
Ann Rheum Dis. 2022 doi: 10.1136/annrheumdis-2022-222586
Observational study of data, from large international collective of registers, finds similar overall drug retention rates between RA treatment groups.
The addition of JAKinibs to the armoury of RA therapy means clinicians, and patients with RA and an inadequate response/contraindication to csDMARDs, now have several second-line therapy options to choose from.
In the absence of head-to-head clinical trials, registry data provide a unique opportunity to compare available treatment options and understand the effectiveness of these therapies in clinical situations.
To this end, Lauper, et al. used data from 19 registers to evaluate and compare the real-world effectiveness of four different second-line therapies; TNFi, ABA, IL-6i and JAKinib.
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